IBTA e-News – September 2012

By 15th September 2012e-News Archive

Dear Friend,

Fasting and therapy for brain tumours: In an Open Access study appearing in PLOS One researchers have identified a beneficial role for controlled starving (fasting) in the sensitisation of rat, mouse and human cells to radiation therapy and chemotherapy (TMZ). A corresponding author Professor Valter Longo commented that patients should consult with their oncologist before undertaking any fasting: "You want to balance the risks. You have to do it right. But if the conditions are such that you've run out of options, short-term fasting may represent an important possibility for patients."

Brain metastases: A Cochrane review of whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases concluded that their "Analysis of all included patients, SRS plus WBRT, did not show a survival benefit over WBRT alone. However, performance status and local control were significantly better in the SRS plus WBRT group. Furthermore, significantly longer OS was reported in the combined treatment group for recursive partitioning analysis (RPA) Class I patients as well as patients with single metastasis."

Blue asbestos and brain tumours: A study of people who were exposed to blue asbestos in childhood in Western Australia has found that both males and females have elevated numbers of brain cancers compared with the general population of that State.

Improved nanoparticles: Researchers at Johns Hopkins (USA) have found a way to improve the inflitration of nanoparticles into the brain by coating nano-sized plastic beads with PEG (poly (ethylene glycol). Their next step is to slow tumour growth or recurrence in rodents.

Green tea and cognitive function: Chinese researchers have found that a key property of green tea (EGCG epigallocatechin-3 gallate) can improve cognitive function by impacting the generation of neuron cells. You can access the full article here.

Depleting miR-138 and glioblastoma: Singaporean researchers in collaboration with Austrian researchers have shown that using antimiR-138 on mouse models could halt the progression of glioblastoma tumours and reduce the likelihood of a relapse.

Childhood cancer: On 31 August the US President Barack Obama proclaimed September 2012 as National Childhood Cancer Awareness Month.

US Home Depot and brain tumour employee: A Home Depot store in Maryland has lost a $100,000 lawsuit after the store fired a longtime cashier while she was on unpaid leave to have a brain tumor removed.

AZD7451: US researchers will be initiating a Phase 1 trial of AZD7451, which is a Tropomyosin-Receptor Kinase (TRK) Inhibitor. They will be studying the effect of the drug on the invasiveness of glioblastoma in patients who have not responded to standard postoperative therapy or whose tumour has progressed.

PNET and Folic Acid fortification: A study of childhood cancer incidence trends in association with the US FDA's mandated fortification of foods with folic acid has indicated a possible connection between reduced primitive neuroectodermal tumor (PNET) rates and a 1992 recommendation that women of childbearing age consume 400 micrograms of folic acid daily. See also here.

Northwest Biotherapeutics: Northwest Biotherapeutics has obtained approval from the UK Medicines and Healthcare Products Regulatory Agency (MHRA) for its Phase III clinical trial of DCVax-L immune therapy to proceed in the UK.

BiCNU (Carmustine) and BMS: Bristol-Myers Squibb is recalling 31,000 units of BiCNU, an injectable version of the drug carmustine, after discovering one vial was overfilled. The recall affects products sold in the US, Canada, Europe, Latin America and Asia-Pacific. Carmustine is used to treat brain tumours.

Afinitor Disperz: The U.S. Food and Drug Administration has approved the Novartis therapy Afinitor Disperz (everolimus tablets for oral suspension), a new pediatric dosage form of the anti-cancer drug Afinitor (everolimus) used to treat a rare brain tumor called subependymal giant cell astrocytoma (SEGA). Afinitor Disperz is the first approved pediatric-specific dosage form developed for the treatment of a pediatric tumor.

Hong Kong: A Hong Kong charity, St James Settlement, will provide subsidies of up to HK$56,000 each to 25 patients who have a glioblastoma brain tumour and cannot access temozolomide through the Hospital Authority.

Deadline: The deadline for the lowest registration rates for the Society for Neuro-Oncology Conference in Washington in November is 15 October.

Crowdfunding: Crowdfunding is a way of utilising digital connections to raise funds for various projects, usually of an entrepreneurial nature. While we are unlikely to see it used to raise funds for drug discovery a group of US-based video game designers are using the method to try and cover the anticipated treatment costs for an uninsured colleague who has a glioblastoma brain tumour.

European readers only: In the July 2012 issue of the IBTA e-news, we mentioned the Rare Cancers Europe (RCE) survey about access to rare cancer care in Europe. The deadline for completing the survey has now been extended to 31 October 2012.  We would be grateful if readers of the IBTA e-news living in the EU 27 countries could complete this survey which is being conducted with the assistance of the Swedish Institute for Health Economics.  Here is the link to the survey: https://sv.surveymonkey.com/s/rarecancers

Correction: It has been pointed out to us that the large (71,793 person) Patient Experience Survey, reported in the August issue of the IBTA E-News, which showed poor results for brain tumour patients, encompassed the views of patients only in the UK and not Scottish or Welsh patients.

Thank you for your continuing support.

Denis Strangman (Chair and Co-Director)
International Brain Tumour Alliance IBTA
www.theibta.org

Kathy Oliver (Co-Director)
PO Box 244, Tadworth, Surrey
KT20 5WQ, United Kingdom
Tel:+ (44) + (0) + 1737 813872
Fax: + (44) + (0) +1737 812712
Mob: + (44) + (0) + 777 571 2569

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