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e-News Archive

IBTA e-News – May 2014

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Treat some low grade gliomas (LGG) differently: In a presentation at the American Association for Cancer Research (AACR) Annual Meeting US researchers suggested that “Based on integrated analysis of genome, transcriptome, methylome and proteome we showed that LGG naturally separates into three distinct groups that traversed grades and histologies. Importantly, we identified a subtype with an LGG-like histology but a molecular GBM profile, suggesting that the GBM standard of care, concomitant radiotherapy and temozolomide, may be warranted for these patients. We propose that classification of LGG should be revised based on IDH1/IDH2 mutation and 1p/19q deletion status.” Comment: To date the general approach to LGG brain tumours has been to not automatically apply therapies that have been established for glioblastoma (GBM). This new suggestion, which is based on analysed data from The Cancer Genome Atlas (TCGA) brain tumor studies, might lead to altered clinical practice….

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IBTA e-News – April 2014

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The cost of premature cancer-related mortality: In an important study which looked at the cost of premature cancer-related mortality in Ireland in 2009 and which was published as recently as 26 March 2014, researchers have confirmed that the cost to the community of the deaths of people with brain and CNS tumours is disproportionate to the incidence and ranking of the disease…

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IBTA e-News – March 2014

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Comprehensive listing of glioblastoma clinical trials: In a unique listing the (US) National Cancer Institute (NCI) has assembled a list of 165 “NCI-supported adult GBM clinical trials that are now accepting patients”. Each entry in the listing provides basic information about the trial with links to more detailed information, including a link to the relevant entry in the authoritative clinicaltrials.gov website. Comment – Our thanks to brain tumor activist Cindi Rixey Scott for drawing the attention of the brain tumour community to this list…

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IBTA e-News – February 2014

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Low-grade glioma and chemotherapy: In 2012 Shaw et al reported early results from the Radiation Therapy Oncology (RTOG) Study 9802 of radiation therapy followed by procarbazine, lomustine and vincristine chemotherapy. In the February 10, 2013 issue of the Journal of Clinical Oncology Marc C. Chamberlain in a letter referred to the “apparent premature reporting of trial results” from this particular trial. However, in a media release from the US National Cancer Institute (NCI) on 3 February 2014 the NCI had noted that those who received the chemotherapy regimen lived longer and that all the chemotherapy drugs are commercially available. It warned of possible toxicities while quoting co-lead investigator Dr Jan Buckner as saying “The results of this study are practice-changing”. Comment – The IBTA makes no recommendation as to what low grade glioma patients should do in terms of their treatment but we suggest that they bring these reports to the notice of their clinician if not already aware of them…

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